2020 Sep;6(5):283-286. doi: 10.1159/000509063. NLM Female Pattern Hair Loss (FPHL), also known as female hair thinning or female androgenetic alopecia is a common type of hair loss that affects about one-third of women. 2007 Feb;48(1):43-5. doi: 10.1111/j.1440-0960.2007.00332.x. 9) Minoxidil: mechanisms of action on hair growth. It is scored so that it can be split if necessary. Recently there has been increased interest worldwide in understand the potential benefits of using low dose oral minoxidil to treat hair loss. Many patients give up after a period of time. Oral minoxidil has been around for many decades and was originally used as a blood pressure medication. Referencias bibliográficas: SINCLAIR RD. The combination of 0.25 mg minoxidil and 25 mg of spironolactone may prove to be the best option as the low dose of OM limits side effects while spironolactone aids in reducing fluid/sodium retention properties of minoxidil. The most common side effects is the increased hair on the face (especially upper lip) and body that some patients get. 2019 Aug 9;13:2777-2786. doi: 10.2147/DDDT.S214907. 2018. Low-dose oral minoxidil (0.25mg daily) has been successfully used in combination with spironolactone in the treatment of female pattern hair loss (FPHL) 1.Oral minoxidil (5mg daily) has been shown to be efficacious in male pattern hair loss (MPHL) 2,3.The objective of our study was to evaluate the efficacy and safety of low-dose sublingual minoxidil (0.45mg daily) in MPHL and FPHL. All causes of hyperandrogenism, such as ovarian or adrenal tumours, polycystic ovarian syndrome and adrenal hyperplasia, can induce rapid hair loss in women. The dose of minoxidil prescribed was 0.25 mg and the dose of spironolactone used was 25 mg. 100 women were included in this study. 1. 2019 Feb;20(1):147-153. doi: 10.1007/s40257-018-0387-0. Minoxidil can be used in adults and children (although its effectiveness and safety in children have been understudied). Minoxidil and spironolactone are oral antihypertensives known to stimulate hair growth. The ease of taking oral minoxidil vs topical minoxidil does make it a important option for further study. Background: Both minoxidil and spironolactone were actually first utilized to treat hypertension. Note Spironolactone and Minoxidil should never be combined in the same lotion due to instability issues. Forty women received spironolactone 200 mg daily and 40 women received cyproterone acetate, either 50 mg daily or 100 mg for 10 days per month if premenopausal. The diagnosis of FPHL is associated with underlying hypertension in women aged £35 years and coronary artery disease in women aged £50 years.7 One study found that patterned hair loss was an in… Discussion: Oral minoxidil is available as a 2.5-milligram (mg) and 10-mg white pill. Suchonwanit P, Iamsumang W, Rojhirunsakool S. Am J Clin Dermatol. HOME        RESEARCH     BIO - DR. DONOVAN     DAILY BLOG     CONTACT US, 4370 Lorimer Road, Suite 334B Whistler, BC, Canada (604) 283-1887. The mean age was 48.44 years and the mean duration of diagnosis was 6.5 years. Treatment of chronic telogen effluvium with oral minoxidil: A retrospective study. Minoxidil and its use in hair disorders: a review. When taken separately, each of … 2018 Jan;57(1):104-109. doi: 10.1111/ijd.13838. Its use in hair loss is entirely off label. Oral Minoxidil . I was first inspired to consider it by presentation by Dr SInclair a few years back. This study is interesting because of the safety and limited side effects that were observed. Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone.Int. Prospective, uncontrolled, open-label observational study. 2018 Nov-Dec; 31(6): e12707. COVID-19 is an emerging, rapidly evolving situation. Over time, the patient notices decreased hair density and a more see through appearance to the scalp. Mean change in blood pressure was -4.52 mmHg systolic and -6.48 mmHg diastolic. Abstract Background Minoxidil and spironolactone are oral antihypertensives known to stimulate hair growth. It is known to increase hair growth on the body as a side effects. Rossi A, Cantisani C, Melis L, Iorio A, Scali E, Calvieri S. Recent Pat Inflamm Allergy Drug Discov. 2. The content of this website is intended to provide accurate, up-to-date and scientifically-based information on all aspects of hair loss. The dose of minoxidil prescribed was 0.25 mg and the dose of spironolactone used was 25 mg. 100 women were included in this study. Minoxidil Topical rated 5.5/10 vs Spironolactone rated 7.3/10 in overall patient satisfaction. J. Dermatol. To report on a case series of women with pattern hair loss (PHL) treated with once daily minoxidil 0.25 mg and spironolactone 25 mg. Methods: Other less common side effects are typically headaches, ankle swelling, hives. To report on a case series of women with pattern hair loss (PHL) treated with once daily minoxidil 0.25 mg and spironolactone 25 mg.  |  The children subsequently developed a condition called “werewolf syndrome” in which large parts of their bodies become covered in hair. Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone. Background: Minoxidil and spironolactone are oral antihypertensives known to stimulate hair growth. I think minoxidil is a very specialist product and if you were to stop oral minoxidil some hairs would be lost unless you replaced with something similar i.e topical minoxidil. 1) Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone. This is an interesting study. Background. Results: Epub 2020 Sep 24. Only 2 of the 100 patients overall discontinued treatment and these were patients with hives (urticaria). Recent Pat Inflamm Allergy Drug Discov. Minoxidil and spironolactone are oral antihypertensives known to stimulate hair growth. Rod Sinclair from Australia set out to study the potential benefits of using oral minoxidil and oral spironolactone together. Epub 2020 Feb 21. Overall the drug combination reduced shedding and reduced hair loss. Sinclair RD, International Journal of Dermatol, 2018, Jan;57 (1): 104-108.  |  National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. The use of oral minoxidil is FDA approved for high blood pressure. Background: Minoxidil and spironolactone are oral antihypertensives known to stimulate hair growth. 3 The use of topical minoxidil together with an oral antiandrogen might have an additive effect; however, combination therapy has not been previously reported. USA.gov. Objective To report on a case series of women with pattern hair loss (PHL) treated with once daily minoxidil 0.25 mg and spironolactone 25 mg. It has long been known that the combination of topical minoxidil and oral spirionlactone (at higher does) are beneficial to FPHL. Dermatol Ther . Limitations: In fact, it was Dr Sinclair who showed this many years ago as well. Some of the benefits of using a combination of low dose oral Minoxidil and Spironolactone include: Improvements in the parietal scalp, and Improvements in temporal hair growth share. Rather than using the 10-40 mg doses that were once used to treat blood pressure, low dose oral minoxidil for hair loss involves doses ranging from 0.25 mg to 2.5 mg. Rod Sinclair from Australia set out to study the potential benefits of using oral minoxidil and oral spironolactone together. Dizziness, headaches, hives, ankle swelling are among the other side effects. If you are going to use or prescribe oral minoxidil, you need to know a thing or two (or three) about it - … Messenger AG 1, Rundegren J., Br J Dermatol, 2004 Feb; 150 (2): 186-94 Mean duration of diagnosis was 6.5 years (range 0.5-30). F1000Res. Has anyone had any experience with this? Together, these studies speak to a relatively good safety profile of oral minoxidil. The mean age was 48.44 years and the mean duration of diagnosis was 6.5 years. Surprisingly, shedding does not tend to be very common when starting. Application of minoxidil does have it's own unique set of challenges. Most women affected by the condition start with slightly increased hair shedding. Pindado-Ortega C, Saceda-Corralo D, Fernández-Nieto D, Jiménez-Cauhé J, Ortega-Quijano D, Moreno-Arrones ÓM, Vañó-Galván S. Skin Appendage Disord. 2020 Jun;6(3):175-176. doi: 10.1159/000505820. Mean reduction in hair shedding score was 2.3 at 6 months and 2.6 at 12 months. Efficacy of Topical Combination of 0.25% Finasteride and 3% Minoxidil Versus 3% Minoxidil Solution in Female Pattern Hair Loss: A Randomized, Double-Blind, Controlled Study. The subject was initially treated with a 200 mg oral dose of spironolactone daily. Objective. Our Laboratory also produces a prescription range of hair lotions which can include Minoxidil, Retinoic acid, finasteride, progesterone and spironolactone. OBJECTIVE To report on a case series of women with pattern hair loss (PHL) treated with once daily minoxidil 0.25 mg and spironolactone 25 mg. Mean hair loss severity at baseline was Sinclair 2.79 (range 2-5). 8) Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone. It was discovered that patients taking these drugs were … hide. This site needs JavaScript to work properly. Low-Dose Oral Minoxidil for Female Pattern Hair Loss: A Unicenter Descriptive Study of 148 Women. - BEGIN YOUR TELEMEDICINE CONSULT NOW, PLANNING YOUR FIRST VISIT WITH DR. DONOVAN, FREQUENTLY ASKED QUESTIONS ABOUT THE FIRST VISIT, FREQUENTLY ASKED QUESTIONS ABOUT SUBSEQUENT APPOINTMENTS, INFORMATION ON FOLLOW UP APPOINTMENT FREQUENCY, SEND US DOCUMENTS AND PHOTOS (SECURE UPLOAD LINK), Referral Information & Form for Physicians, Dr. Donovan's Hair Loss Articles (2011-2020), Combining Oral Minoxidil and Oral Spironolactone for FPHL. Australas J Dermatol. Only 2 % of patients dropped out of the study. But i did not lose much if any ground switching from Oral spironolactone to topical RU after a few years because they have similar modes of action. Minoxidil and spironolactone are oral antihypertensives known to stimulate hair growth. Compare Minoxidil Topical vs Spironolactone head-to-head with other drugs for uses, ratings, cost, side effects and interactions. The ease of taking oral minoxidil vs topical minoxidil does make it a important option for further study. Spironolactone is androgen dependent and has been approved for treating high blood pressure, but is not commercially available for hair loss. Six of these women continued treatment, and two women who developed urticaria discontinued treatment. Any affects on your face/skin texture.. or affects on scalp? Suchonwanit P, Thammarucha S, Leerunyakul K. Drug Des Devel Ther. Efficacy and Safety of Oral Minoxidil 5 mg Once Daily in the Treatment of Male Patients with Androgenetic Alopecia: An Open-Label and Global Photographic Assessment. Learn about drug interactions between minoxidil oral and spironolactone oral and use the RxList drug interaction checker to check drug combinations. Luckily, the body hair will disappear a few months after the children stop taking oral Minoxidil. Case series of oral minoxidil for androgenetic and traction alopecia: Tolerability & the five C’s of oral therapy. Once a day over 12 months, each woman took a capsule that contained 25 milligrams (mg) of spironolactone and 0.25 mg of oral minoxidil. How long before you saw results and have you had any side effects. Mean age was 48.44 years (range 18-80). 2 The mechanism of action of minoxidil is unknown, but does not involve androgen pathways. Female pattern hair loss: a pilot study investigating combination therapy with low-dose oral minoxidil and spironolactone. Please enable it to take advantage of the complete set of features! Int J Dermatol. 8 % of patients in the study have side effects but they were deemed mild. It should not be considered a substitute for professional medical advice. Treatment of female pattern hair loss with a combination of spironolactone and minoxidil. Minoxidil was first introduced as an oral medication for the treatment of severe and recalcitrant hypertension in the 1970s. Dermatol Ther (Heidelb). Other options including oral anti-androgens, laser, PRP and hair transplantation (for some women). 2020 Dec;10(6):1345-1357. doi: 10.1007/s13555-020-00448-x. And alternative options – such as scalp massage and microneedling – also exist. Prescribing Habits for Androgenic Alopecia among Dermatologists in Spain in 2019-2020: A Cross-Sectional Study. No patients developed hyperkalemia or any other blood test abnormality. save. Indian Dermatol Online J. Women newly diagnosed with a Sinclair stage 2-5 PHL were scored for hair shedding and hair density before and after 12 months of treatment with oral minoxidil 0.25 mg and spironolactone 25 mg. 2020 Jul 13;11(4):493-501. doi: 10.4103/idoj.IDOJ_334_19. As alopecia is highly visible, a patient may note hair loss as the first symptom of a host of underlying or contributing medical and psychiatric conditions. Minoxidil use in dermatology, side effects and recent patents. More studies of oral minoxidil are needed but studied to date are promising. Oral Minoxidil Excessive Body Hair Increase Side Effect. 0 comments. 2017 Sep 6;6:1650. doi: 10.12688/f1000research.11775.1. Website Disclaimer, Scarring Alopecia - Frequently Asked Questions, Alopecia areata - Frequently Asked Questions, Our International Hair Loss Course for Physicians, APPOINTMENT TODAY? In another study by Dr. Sinclair (of chronic telogen effluvium) which also involved study of oral minoxidil, there were no drop outs. 1 Coincidentally, physicians observed hair regrowth and generalized hypertrichosis in balding patients, which led to the development of a topical minoxidil formulation for treating androgenetic alopecia (AGA) first in male and then in female individuals. © 2017 The International Society of Dermatology. Rodney D. Sinclair, Female pattern hair loss: a pilot study investigating combination therapy with low‐dose oral minoxidil and spironolactone, International Journal of Dermatology, 10.1111/ijd.13838, 57, 1, (104-109), (2017). Objective: Hi anyone taking 0.625 mg Oral Minoxidil along with 25mg spironolactone? (Nobody in the world has more experience with oral minoxidil for hair loss than Dr. Sinclair). eCollection 2017. Oral Minoxidil and Spiro. 2012 May;6(2):130-6. doi: 10.2174/187221312800166859. Epub 2017 Dec 12. HHS There was a slight reduction in mean blood pressure of 4.52 mmHg systolic and 6.48 mgHg diastolic. A total of 100 women were included in this observational pilot study. NIH It was at this point in the study that a twice daily dose of minoxidil 5% solution was prescribed, and further hair regrowth was documented. But when it comes right down to it, the fact of the matter is you need to treat the underlying cause of your condition if you want to stop hair loss and perhaps even regrow your hair. Hi there, I’m a 25 year old who just started on oral minoxidil 0.25mg and 25mg spironolactone. What sort of … Antiandrogen therapy with either spironolactone or cyproterone acetate is commonly used to treat FPHL, as is topical minoxidil. Oral minoxidil is not FDA approved for hair loss. She had documented hair regrowth at the 12-month mark, though, hair growth did eventually plateau by the 24-month mark. 2) Effectiveness and safety of low-dose oral minoxidil in male androgenetic alopecia. Mean hair shedding score at baseline was 4.82. [The treatment of female pattern hair loss]. Placebo-controlled studies to investigate this further are warranted.  |  Once daily capsules containing minoxidil 0.25 mg and spironolactone 25 mg appear to be safe and effective in the treatment of FPHL. 2012. The most common side effect in practice is increased hair on the upper lip in 25- 35 % of women. HealthDay News — Once-daily capsules containing a combination of minoxidil and spironolactone appear to be safe and effective for the treatment of … Clipboard, Search History, and several other advanced features are temporarily unavailable. 2018; JIMENEZ J., SACEDA CORRALO D. RODRIGUEZ BARATA R., VAÑÓ-GALVAN S. Effectiveness and safety of low-dose oral minoxidil in male androgenetic alopecia.JAAD , 2019 , May. This condition is also referred to as hypertrichosis. Sinclair RD. Side effects of oral minoxidil therapy are dose related and include low blood pressure, increased heart rate and fluid retention (see page 3). Oral minoxidil for hair loss At Salford Royal, patients are considered eligible for oral minoxidil treatment if their hair loss has not responded to topical minoxidil or if these products are not tolerated. eCollection 2020 Jul-Aug. Rodrigues-Barata R, Moreno-Arrones OM, Saceda-Corralo D, Jiménez-Cauhé J, Ortega-Quijano D, Fernández-Nieto D, Jaén-Olasolo P, Vaño-Galvan S. Skin Appendage Disord. Minoxidil (Rogaine) and spironolactone are used widely by women with hair loss to slow shedding and induce growth. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. See Article “The Top 10 Things You need to Know About Oral Minoxidil”. alopecia with oral minoxidil either alone or in combination with antiandrogens on 18 August 2011. Int J Dermatol. Introduction. Learn about drug interactions between spironolactone oral and minoxidil oral and use the RxList drug interaction checker to check drug combinations. Mean reduction in hair loss severity score was 0.85 at 6 months and 1.3 at 12 months. Topical Minoxidil remains the only formally FDA and Health Canada approved treatment for FPHL. We have been using oral minoxidil in clinic for some time. eCollection 2019. Sinclair RD. Epub 2020 Jul 20. Side effects were seen in eight women but were generally mild. All photos and information in this website is copyrighted unless otherwise stated.